http://hdl.handle.net/20.500.12323/1279 2026-10-20T21:48:00Z http://hdl.handle.net/20.500.12323/8401 Title: Associations between lifestyle, genetic liability for severe mental illness and risk of incident somatic illnesses Authors: Isayeva, Ulker; Guloksuz, Sinan; Lin, Bochao Danae; de Boer, Nini; Rutten, Bart P. F.; Linden, David E. J.; Manchia, Mirko; Luykx, Jurjen J. Abstract: People with severe mental illness (SMI), including schizophrenia (SCZ) and bipolar disorder (BD), show elevated risk for somatic conditions and premature mortality. Both genetic liability and modifiable lifestyle factors have been implicated in this comorbidity, yet large-scale studies examining their independent and combined effects across multiple somatic conditions are lacking. We therefore examined whether modifiable lifestyle factors (i.e. smoking, alcohol intake, diet, and exercise) and polygenic risk scores (PRS) for SCZ and BD are associated with the risk of developing somatic illnesses. Data were drawn from 315,313 unrelated individuals in the UK Biobank cohort, with a median follow up of 14 years. Cox proportional hazards models were used to estimate the independent, joint, and interaction effects of PRS-SCZ and PRS-BD and lifestyle factors on the incidence of nine chronic somatic illnesses. Healthy lifestyle was associated with lower risks of type 2 diabetes (T2D), cardiovascular disease (CVD), dementia, rheumatoid arthritis, asthma, chronic liver disease (CLD), and cancer (HRs ranging from 0.43 to 0.80). In addition, higher PRS for SCZ was associated with increased risks of asthma and dementia and lower risk of T2D, while higher PRS for BD was associated with increased risk of T2D. Moreover, likelihood ratio tests confirmed that PRS-SCZ and PRS-BD each contribute independent information to the joint Cox model for T2D, indicating that the opposing directions of their associations with T2D risk are not driven by shared genetic variance between the two scores. Finally, individuals with a healthy lifestyle consistently showed lower risks of CLD, T2D, CVD, and dementia across genetic risk strata; however, no significant additive interaction was observed between genetic risk and lifestyle factors. In conclusion, these findings indicate that genetic liabilities for SCZ and BD show outcome-specific associations with somatic illnesses, while a healthy lifestyle is associated with lower somatic illness risk regardless of genetic risk level. 2026-08-07T00:00:00Z http://hdl.handle.net/20.500.12323/8369 Title: Opinion: A Routine Visit, a Revealing Reaction Authors: Huseynov, Vasif 2026-09-17T00:00:00Z http://hdl.handle.net/20.500.12323/8368 Title: Sufism And Personalism: Philosophical and Ethical Conceptions of God and The Person Authors: Garayeva, Gunel Aliniyaz; Khalilov, Ruslan Niyaz Abstract: This article compares and analyzes Sufism and American personalist as two distinct intellectual traditions. Although they emerged in distinct historical and cultural contexts, but they conceptualized the human being as a holder of moral value, dignity, creative potential, spiritual embodiment. Tasavvuf expresses union with God and a spiritual journey to divine love, this path constitutes a profound ontological transformation of the Sufi practitioner. In the modern world a crisis of identity, cultural conflict, relativism in morality changed the value of humanity and for this reason the dialogue of sufy and personalist currents is a new highly valued philosophical approach. The coordination of the spiritual depth of Islamic-eastern philosophy and American-western ethics of responsibility as social issue opens new achievements in cultural dialogue and individual self-perfection. The synthesis of Sufism and American personalism creates a new model of “spiritual humanism”, here ethical and anthropological parallels are a new systematic analytical identification. Based on philosophical synthesis it formulates the idea of a “transcultural personalism embedded in spiritual responsibility”. The comparative philosophical ideas produce a spiritual-philosophical framework: from Sufism it adopts the ideas of love, mystical intuition, ontological unity, from Personalism it derives rational justification of responsibility, freedom, human dignity. Through this dialectical integration the human is accepted as a metaphysical reflection of the absolute essence and as an ethical-subjective actor in historical process. Both philosophical schools hold that the human being is responsible toward mankind and God. Sufism sees the implementation of these duties in spiritual perfection, in the same issue personalism realizes it by understanding the importance of social responsibility and ethical consciousness. As a final analysis, the sufi philosophy on “silent journey guiding the human existence toward the Divine” resonates with American personalism in its understanding of God`s manifestation with human being. Each philosophical study evaluates the human as a center of spiritual universe and claims that divine worth of person is the most significant philosophical truth. Overall, this approach provides a productive conceptual foundation not only for interreligious encounter, but also for the evolution of humanism in global philosophical thought. Emerging from the dialogue of Islamic mysticism and American-western personalism in the twenty first century the discussion offers a significant philosophical direction for reconsidering the concepts of the humanity, responsibility, spirituality. 2026-03-01T00:00:00Z http://hdl.handle.net/20.500.12323/8362 Title: Integrated care programmes for severe mental illnesses and comorbid physical health disorders: the EU-MIND umbrella review to inform future actions in Europe Authors: Isayeva, Ulker; Touitou-Burckard, Esther; Bukowska, Alicja; Cichoń, Ewelina; Gondek, Tomasz; Todzia-Kornaś, Agata; Rahmati, Masoud; Gandré, Coralie; Kiejna, Andrzej; Manchia, Mirko; Boyer, Laurent; EU-MIND Consortium Collaborators Abstract: Evidence before this study People with severe mental illness (SMI) experience a markedly elevated burden of physical comorbidity and premature mortality. Although integrated care has long been proposed as a strategy to address fragmentation between mental and physical healthcare services, the organisational features of effective and scalable programmes remain unclear. We searched PubMed, Scopus, PsycINFO, and the Cochrane Library from database inception to 5 May 2026 for review-level evidence on integrated care programmes for individuals with SMI and co-occurring physical conditions or major social vulnerabilities. Search terms included combinations of “severe mental illness”, “serious mental illness”, “integrated care”, “collaborative care”, “coordinated care”, and “multimorbidity”. We included systematic reviews, scoping reviews, and meta-analyses restricted to seven predefined European languages. Existing reviews describe various integrated care approaches and report improvements in access to care and preventive services. However, evidence on physical health outcomes, governance, financing, and implementation processes, remains limited and inconsistently reported. Added value of this study This umbrella review provides a structured synthesis of the organisational components, reported impacts, and implementation challenges of integrated care programmes for people with SMI using the SELFIE framework for multimorbidity-oriented integrated care. By mapping these programmes across service delivery, governance, workforce, financing, technology, and research domains, we identify persistent system-level gaps that constrain scalability and sustainability. The review highlights the predominance of pilot-based initiatives and the limited evidence supporting improvements beyond care processes. Implications of all the available evidence Current evidence suggests that integrated care programmes can improve access to primary and preventive services for people with SMI, but their broader impact on physical health and social outcomes remains modest. Strengthening macro-level governance, sustainable financing mechanisms, digital infrastructure, and cross-sector coordination will be critical to translate promising pilot initiatives into scalable health system reforms. These findings inform the next phase of the EU-MIND initiative, which will engage stakeholders to develop consensus-based guidance for implementing sustainable integrated care across diverse European health systems. 2026-08-01T00:00:00Z