The Properties and Clinical use of Polyene Antibiotics

Abstract

Model membranes' similarity to the biological cell membrane and their simple structure with controlled composition and properties. They are formed from natural and synthetic lipids, and these membranes are an interesting object for scientific investigations. We studied the ultraviolet absorption spectrum of the complex formed by polyene antibiotics at different concentrations separately and stable with cholesterol. We also study the effects of the antibiotic concentration and channel-expression and the dynamics of channels, which are affected by pH in lipid membranes. We represent and define the behavior of such antibiotic-generated-channels over a wide range of pH values and ionic strength. Our information demonstrates the pH-induced modulation of AmB channels selectivity, stability of the open state, and conductance. This work might be of widespread importance for comprehending molecular aspects regarding fundamental properties of AmB, such as activity, toxicity, and formation of ion channels, and provide a more suitable familiarity. Learning mechanism help to develop a more unassailable AMB formulation for treatment.