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|Title:||Uric acid and thiocyanate as competing substrates of lactoperoxidase|
Khalilova, Irada S.
Wilbanks, Sigurd M.
Kettle, Anthony J.
Jameson, Guy N. L.
|Publisher:||American Society for Biochemistry and Molecular Biology|
|Citation:||Journal of Biological Chemistry|
|Series/Report no.:||Vol. 289;№ 32|
|Abstract:||The physiological function of urate is poorly understood. It may act as a danger signal, an antioxidant, or a substrate for heme peroxidases. Whether it reacts sufficiently rapidly with lactoperoxidase (LPO) to act as a physiological substrate remains unknown. LPO is a mammalian peroxidase that plays a key role in the innate immune defense by oxidizing thiocyanate to the bactericidal and fungicidal agent hypothiocyanite. We now demonstrate that urate is a good substrate for bovine LPO.|
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