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http://hdl.handle.net/20.500.12323/4752| Title: | Uric acid and thiocyanate as competing substrates of lactoperoxidase |
| Authors: | Seidel, Antonia Turner, Rufus Dickerhof, Nina Khalilova, Irada S. Wilbanks, Sigurd M. Kettle, Anthony J. Jameson, Guy N. L. Parker, Heather |
| Issue Date: | Aug-2014 |
| Publisher: | American Society for Biochemistry and Molecular Biology |
| Citation: | Journal of Biological Chemistry |
| Series/Report no.: | Vol. 289;№ 32 |
| Abstract: | The physiological function of urate is poorly understood. It may act as a danger signal, an antioxidant, or a substrate for heme peroxidases. Whether it reacts sufficiently rapidly with lactoperoxidase (LPO) to act as a physiological substrate remains unknown. LPO is a mammalian peroxidase that plays a key role in the innate immune defense by oxidizing thiocyanate to the bactericidal and fungicidal agent hypothiocyanite. We now demonstrate that urate is a good substrate for bovine LPO. |
| URI: | http://hdl.handle.net/20.500.12323/4752 |
| Appears in Collections: | Publications |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Uric acid and thiocyanate as competing substrates of lactoperoxidase.pdf | 1.86 MB | Adobe PDF | View/Open |
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